pentobarbital will reduce the extent or outcome of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.pentobarbital will reduce the extent or effect of diltiazem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lessen the level or effect of acalabrutini